Muscle Extracellular Matrix Scaffold Is a Multipotent Environment
نویسندگان
چکیده
منابع مشابه
Muscle Extracellular Matrix Scaffold Is a Multipotent Environment
The multipotency of scaffolds is a new concept. Skeletal muscle acellular scaffolds (MAS) implanted at the interface of Tibialis Anterior/tibial bone and masseter muscle/mandible bone in a murine model were colonized by muscle cells near the host muscle and by bone-cartilaginous tissues near the host bone, thus highlighting the importance of the environment in directing cell homing and differen...
متن کاملBiologic scaffold composed of skeletal muscle extracellular matrix.
Biologic scaffolds prepared from the extracellular matrix (ECM) of decellularized mammalian tissues have been shown to facilitate constructive remodeling in injured tissues such as skeletal muscle, the esophagus, and lower urinary tract, among others. The ECM of every tissue has a unique composition and structure that likely has direct effects on the host response and it is plausible that ECM h...
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BACKGROUND Heart failure remains a significant problem. Tissue-engineered cardiac patches offer potential to treat severe heart failure. We studied an extracellular matrix scaffold for repairing the infarcted left ventricle. METHODS AND RESULTS Pigs (n=42) underwent left ventricular (LV) infarction. At 6 to 8 weeks, either 4-layer multilaminate urinary bladder-derived extracellular matrix or ...
متن کاملThe extracellular matrix as a biologic scaffold for tissue engineering
● To understand the composition and organization of extracellular matrix (ECM) in tissues and organs ● To recognize the utility of scaffolds derived from ECM in the field of tissue engineering ● To comprehend the importance of mechanical behavior and mechanical design in the use of ECM scaffolds for tissue repair ● To identify the process by which ECM scaffolds are produced ● To understand some...
متن کاملThe extracellular matrix as a biologic scaffold material.
Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) have received significant attention for their potential therapeutic applications. The full potential of the ability of ECM scaffolds to promote constructive remodeling will not be realized, however, until an understanding of the biology and the external influences that affect biology, are better achieved. The factors ...
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ژورنال
عنوان ژورنال: International Journal of Medical Sciences
سال: 2015
ISSN: 1449-1907
DOI: 10.7150/ijms.10761